Milan Uskokovic Selected Research

1,25- dihydroxy- 21- (3- hydroxy- 3- methyl- 4,4,4- tributyl)- 23- yne- 26,27- hexafluorocholecalciferol

4/2015	HES1-mediated inhibition of Notch1 signaling by a Gemini vitamin D analog leads to decreased CD44(+)/CD24(-/low) tumor-initiating subpopulation in basal-like breast cancer.
4/2015	Vitamin D compounds reduce mammosphere formation and decrease expression of putative stem cell markers in breast cancer.
6/2014	Inhibition of the transition of ductal carcinoma in situ to invasive ductal carcinoma by a Gemini vitamin D analog.
9/2013	Oral administration of a gemini vitamin D analog, a synthetic triterpenoid and the combination prevents mammary tumorigenesis driven by ErbB2 overexpression.
1/2013	Targeting CD44-STAT3 signaling by Gemini vitamin D analog leads to inhibition of invasion in basal-like breast cancer.
3/2011	A novel Gemini vitamin D analog represses the expression of a stem cell marker CD44 in breast cancer.
7/2010	Gemini vitamin D analog suppresses ErbB2-positive mammary tumor growth via inhibition of ErbB2/AKT/ERK signaling.

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Milan Uskokovic Research Topics

Disease

13	Neoplasms (Cancer) 04/2015 - 01/2003
10	Breast Neoplasms (Breast Cancer) 04/2015 - 07/2006
7	Hypercalcemia (Milk Alkali Syndrome) 09/2010 - 05/2002
6	Carcinogenesis 09/2013 - 07/2006
3	Neoplasm Metastasis (Metastasis) 04/2015 - 03/2011
3	Prostatic Neoplasms (Prostate Cancer) 03/2007 - 01/2003
3	Leukemia 08/2006 - 06/2006
3	Autoimmune Diseases (Autoimmune Disease) 05/2004 - 05/2002
2	Noninfiltrating Intraductal Carcinoma (DCIS) 04/2015 - 06/2014
2	Myeloid Leukemia (Leukemia, Myelocytic) 06/2006 - 06/2006
2	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 02/2003 - 05/2002
1	Ductal Carcinoma 06/2014
1	Body Weight (Weight, Body) 03/2011
1	Inflammation (Inflammations) 03/2007
1	Colonic Neoplasms (Colon Cancer) 03/2007
1	Prostatitis 03/2007
1	Vitamin D Deficiency 05/2004
1	Hypertension (High Blood Pressure) 05/2004
1	Cardiomegaly (Heart Hypertrophy) 05/2004
1	Alopecia (Baldness) 11/2002
1	Congenital alopecia X-linked 11/2002
1	Bone Diseases (Bone Disease) 05/2002
1	Bone Resorption 05/2002
1	Osteoporosis 05/2002
1	Disease Progression 05/2002

Drug/Important Bio-Agent (IBA)

13	Vitamin D FDA LinkGeneric 04/2015 - 01/2003
9	Cholecalciferol (Vitamin D3)FDA Link 01/2013 - 11/2002
7	1,25- dihydroxy- 21- (3- hydroxy- 3- methyl- 4,4,4- tributyl)- 23- yne- 26,27- hexafluorocholecalciferolIBA 04/2015 - 07/2010
7	1,25-dihydroxyvitamin DIBA 11/2008 - 05/2002
5	Calcitriol Receptors (Calcitriol Receptor)IBA 06/2014 - 11/2002
4	Calcitriol (Calcijex)FDA LinkGeneric 03/2007 - 11/2002
3	Proteins (Proteins, Gene)FDA Link 01/2013 - 08/2006
3	ReninIBA 03/2007 - 05/2004
2	hydroxide ionIBA 04/2015 - 08/2006
2	TriterpenesIBA 09/2013 - 06/2006
2	1- (2- cyano- 3,12- dioxooleana- 1,9- dien- 28- oyl) imidazoleIBA 09/2013 - 06/2006
2	CalciumIBA 03/2011 - 05/2002
2	Estrogen ReceptorsIBA 07/2010 - 11/2008
2	Messenger RNA (mRNA)IBA 03/2007 - 06/2005
2	1,25-dihydroxy-16,23-diene vitamin D3IBA 06/2006 - 01/2003
2	LigandsIBA 05/2004 - 02/2003
1	KalininIBA 06/2014
1	Tyrosine (L-Tyrosine)FDA Link 09/2013
1	ErbB Receptors (EGF Receptor)IBA 09/2013
1	Phosphotransferases (Kinase)IBA 09/2013
1	Glycoproteins (Glycoprotein)IBA 01/2013
1	CarcinogensIBA 07/2010
1	Cyclin-Dependent Kinase Inhibitor p21IBA 11/2008
1	Methylnitrosourea (N-Methyl-N-nitrosourea)IBA 11/2008
1	Insulin-Like Growth Factor Binding Protein 3IBA 11/2008
1	Transforming Growth Factor beta (TGF-beta)IBA 12/2007
1	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 12/2007
1	BXL628IBA 03/2007
1	Carbon-20IBA 08/2006
1	Ro43 83582IBA 07/2006
1	PolyphenolsIBA 06/2006
1	salvinIBA 06/2006
1	bardoxoloneIBA 06/2006
1	Differentiation AntigensIBA 06/2006
1	AcidsIBA 06/2006
1	Carboxylesterase (Hydrolase S)IBA 06/2006
1	AngiotensinsIBA 05/2004
1	KH 1060IBA 01/2003
1	Ro 26-9228IBA 05/2002
1	AutoantigensIBA 05/2002
1	Class 8 Receptor-Like Protein Tyrosine PhosphatasesIBA 05/2002
1	Biomarkers (Surrogate Marker)IBA 05/2002
1	Insulin (Novolin)FDA Link 05/2002
1	Interleukin-12 (IL 12)IBA 05/2002

Therapy/Procedure

4	Therapeutics 04/2015 - 06/2006
1	Oral Administration 09/2013
1	Treatment Delay 09/2013
1	Chemoprevention 06/2006
1	Injections 06/2006
1	Intraperitoneal Injections 01/2003